منابع مشابه
Clonal origin of metastatic testicular teratomas.
PURPOSE Testicular teratomas in adult patients are histologically diverse tumors that frequently coexist with other germ cell tumor (GCT) components. These mixed GCTs often metastasize to retroperitoneal lymph nodes where multiple GCT elements are frequently present in the same metastatic lesion. Neither the genetic relationships among the different components in metastatic lesions nor the rela...
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Altered El Tor Vibrio cholerae O1, with classical cholera toxin B gene, was isolated from 16 patients with severe diarrhea at St. Mark's Hospital, Arbonite, Haiti, <3 weeks after onset of the current cholera epidemic. Variable-number tandem-repeat typing of 187 isolates showed minimal diversity, consistent with a point source for the epidemic.
متن کاملClonal origin of abnormal granulocytes in paroxysmal nocturnal hemoglobinuria.
Two studies recently published in Blood have used the pattern of X-chromosome inactivation to test whether white blood cells of patients with paroxysmal nocturnal hemoglobinuria (PNH) and aplastic anemia (AA) belong to a single The investigators’ conclusions were in keeping with data previously obtained by the same approach on red blood cells? However, we find the interpretation of their findin...
متن کاملClonal origin and spread of metastatic prostate cancer.
Metastatic disease is responsible for the majority of prostate cancer deaths. The standard treatment for metastatic disease is surgical or chemical castration in the form of androgen deprivation therapy. Despite initial success and disease regression, resistance to therapy ultimately develops and the disease transitions to castration-resistant prostate cancer, which is uniformly fatal. Thus, de...
متن کاملClonal origin of a T cell lymphoproliferative malignancy.
A woman with a T cell lymphoproliferative malignacy and heterozhgosity at the X chromosome-linked locus for glucose-6-phosphate dehydrogenase (G-6PD) isoenzymes was studied to find the clonal origin of her circulating neoplastic T cells. The red blood cells, polymorphonuclear cells, whole mononuclear cells, and T cell-depleted mononuclear cells contained both A and B isoenzymes of G-6-PD. In co...
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ژورنال
عنوان ژورنال: Nature Immunology
سال: 2015
ISSN: 1529-2908,1529-2916
DOI: 10.1038/ni.3219